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Which of the following is not true of type III hypersensitivity?


A) The Arthus reaction is a local response.
B) Antigen-antibody complexes are deposited in the basement membrane of epithelial tissues.
C) It involves an immune complex reaction.
D) Serum sickness is a systemic response.
E) It involves production of IgE antibodies.

F) C) and E)
G) A) and E)

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A viral infection can lead to the development of type I diabetes.

A) True
B) False

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You were out in the garage going through boxes when you were bitten by an a spider.You tell the doctor that the spider was tiny and black,causing the doctor to think perhaps that it was a black widow spider The doctor gives you an injection of antibody to the spider venom to give you immediate protection.The antibody is produced in horses by injecting them with small doses of the spider venom,causing the horse's immune system to make large amounts of specific antibody to the antigen.The horse serum is then purified before being given to humans. A. a Staphylococcus infection related to the spider bite. B. serum sickness. C. a delayed type hypersensitivity mediated by cytotoxic T cells along with helper T cells. D. Arthus reaction. E. anaphylactic shock.

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A week later,you notice a red rash sprea...

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Autoantibodies cause tissue injury in all of the following diseases except


A) multiple sclerosis.
B) tuberculin reaction.
C) rheumatoid arthritis.
D) myasthenia gravis.
E) Graves'disease.

F) A) and B)
G) C) and D)

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Food allergies include gastrointestinal symptoms and often hives.

A) True
B) False

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Myasthenia gravis disease arises from the production of autoantibodies against


A) cells in thyroid follicles.
B) sodium pump proteins in the cell membrane.
C) acetylcholine receptors on smooth muscle.
D) myelin sheath cells of the nervous system.
E) acetylcholine receptors on skeletal muscle.

F) D) and E)
G) None of the above

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Which of the following is not a target for immune complex deposition?


A) Heart and lungs
B) Brain
C) Kidneys
D) Joints
E) Blood vessels and skin

F) C) and E)
G) B) and E)

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Autoimmunity is typically due to


A) autoantibodies and T cells.
B) a transfusion reaction.
C) IgE and mast cells.
D) graft rejection.
E) a deficiency in T-cell development.

F) C) and D)
G) A) and E)

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A person who produces anti-A and anti-B serum antibodies will have blood type ______.


A) Rh
B) A
C) AB
D) O
E) B

F) D) and E)
G) A) and B)

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Before a type II hypersensitivity can proceed,three immune components must be in place: complement,IgG,and IgM.

A) True
B) False

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Bee sting venom is considered to be which type of allergen?


A) Injectant
B) Ingestant
C) Inhalant
D) Contactant

E) All of the above
F) A) and D)

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A person with O type blood


A) lacks A and B antigens.
B) is called a universal recipient.
C) lacks all of the alleles for ABO blood type.
D) could not have the Rh factor.

E) B) and D)
F) B) and C)

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Allergic reactions to penicillins are considered a(n) _____ hypersensitivity.


A) T-cell-mediated
B) antibody-mediated
C) immune complex-mediated
D) immediate
E) Both T-cell-mediated and antibody-mediated are correct.

F) C) and D)
G) A) and B)

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Autoimmune diseases and immunodeficiencies are studied and treated by immunopathologists.

A) True
B) False

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Serum sickness and the Arthus reaction are both type III hypersensitivities,but they differ in that


A) serum sickness is a systemic reaction to an injected therapy, whereas the Arthus reaction remains localized to the injection site.
B) serum sickness is an infection in the blood serum, whereas the Arthus reaction is a swelling in the joints.
C) serum sickness is vomiting and diarrhea in response to animal serum, whereas the Arthus reaction causes arthritis.
D) serum sickness is a localized reaction to an injected therapy, whereas the Arthus reaction is systemic.

E) C) and D)
F) B) and D)

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A person who is Rh- will have anti-Rh antibodies in his/her serum from early infancy.

A) True
B) False

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An effective test to determine whether an individual is allergic to a specific substance is to


A) test for the allergen in the blood.
B) test for levels of IgE specific for the allergen.
C) test for high levels of IgG in the serum.
D) inject high levels of the allergen so see if the patient goes into anaphylactic shock.

E) A) and B)
F) A) and C)

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The major category(ies) of hypersensitivity(ies) that typically involve(s) a B-cell immunoglobulin response include(s)


A) type I only.
B) type I and type IV.
C) type IV only.
D) type I, type II, and type III.
E) type I, type II, type III, and type IV.

F) C) and E)
G) A) and B)

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Which of the following is not a possible outcome of a type I hypersensitivity reaction?


A) Diarrhea
B) Rashes
C) Contact dermatitis
D) Sneezing
E) Rhinitis

F) B) and C)
G) A) and D)

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What can be a consequence of a genetic deficiency in B-cell survival and maturity?


A) Graft versus host disease
B) Formation of autoantibodies
C) Hypogammaglobulinemia
D) Host rejection of graft

E) B) and D)
F) All of the above

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